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Note that participants in the previously published pilot study (14) are included in this manuscript due to the fact that the present analysis includes additional metabolites and comparison of all outcomes across product formulations

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(A couple of caveats - first, of course, this was an animal study, and secondly, it only looked at male mice.) Another study by Meineur et al conducted in 2011 (itself sparked by the unexpected findings of the previous 2011 study) found that nicotine sparks the same receptors in brains that are involved in our flight or fight response